Can you give any additional information about Othello Syndrome in the context of PD?


Othello syndrome describes a form of psychosis in which one has delusional thoughts about their partner having an affair or similar relationship that does not exist. They may misinterpret ‘clues’ to support this delusion.

Delusions and hallucinations can be seen with certain psychiatric disorders and in the setting of Parkinson’s disease with the following conditions:
-High dose dopamine medicines especially dopamine agonists, amantadine and selegiline
-Other medicines that can cause confusion such as anticholinergics, muscle relaxants and pain medicines (narcotics)
-Illicit (street) drugs)Cognitive problems suggestive of dementia
-Coexisting medical conditions such as thyroid disease, vitamin deficiency (B12),infection or dehydration

Treatment includes:
-Reducing medicines when possible
-Occupational therapy evaluation to analyze how someone is taking medicines and help family administer medicines in the event the person with PD is taking more than prescribed
-Antipsychotic medicines- namely clozaril or quetiapine
-Cognitive enhancing medicines such as rivastigmine
-Counseling and psychiatric evaluation to evaluate for other conditions
-There is little evidence to date about the effect of a new antipsychotic.
-A combined neurology and psychiatry evaluation may be needed for this difficult problem.

See related article on hallucinations

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1 Comment

Filed under Caregiving, Cognitive Health, Emotional Health, Medication Side Effects

One response to “Can you give any additional information about Othello Syndrome in the context of PD?

  1. dannyboy2401

    I have never heard about Othello syndrome,but it sounds just like compulsive- impulsive behaviour, which have the same symptoms, jealousty, your medication can make you think the most outrageous thoughts about your closest loved ones, I had it bad for 6 years, and I seen myself in such a state that I believed my wife was letting her lovers in through the upstairs bedroom windows, and all of our best friends were suspects. I believe you could fool yourself into believing any wild thoughts, and not blame your meds, Parkinson’s meds should be tested and retested, and warning bells, just a few lines on the instruction sheet with your meds is not good enough, these meds are life changing, and not for the best. More warnings and check ups required. bye Danny

    Daniel Wilson

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